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Eldepryl is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson's disease (sometimes called shaking palsy or paralysis agitans). This medicine works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson's disease.
Active Ingredient: Selegiline
Availability: In Stock (17 packages)
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Analogs of Eldepryl: 
Eldepryl 5mg
Product namePer PillSavingsPer PackOrder
60 pills$0.76$45.60ADD TO CART
90 pills$0.73$3.01$68.40 $65.39ADD TO CART
120 pills$0.71$6.02$91.20 $85.18ADD TO CART
180 pills$0.69$12.04$136.80 $124.76ADD TO CART
270 pills$0.68$21.07$205.20 $184.13ADD TO CART
360 pills$0.68$30.10$273.60 $243.50ADD TO CART

    Eldepryl is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy.


    Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

    It is best to take this medicine before breakfast and without liquids.

    If you are using the disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet on the top of your tongue, where it will melt quickly. Do not eat food or drink liquids for 5 minutes before or after taking this medicine.

    If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


    The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
    For oral dosage form (tablets):
    For Parkinson's disease:

    • Adults—At first, 1.25 milligrams (mg) once a day for at least 6 weeks. After 6 weeks, your doctor may increase your dose to 2.5 mg once a day.
    • Children—Use and dose must be determined by your doctor. Use and dose must be determined by your doctor.


    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
    Keep out of the reach of children.
    Do not keep outdated medicine or medicine no longer needed.


    Eldepryl is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl.


    It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

    Do not take selegiline if you have used meperidine (e.g., Demerol®) or an MAO inhibitor (MAOI) (e.g., isocarboxazid, phenelzine, tranylcypromine, Marplan®, Nardil®, or Parnate®) within the past 14 days. If you do, you may develop agitation, confusion, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, or severe convulsions.

    Do not take cough medicines (e.g., dextromethorphan, Robitussin®, Pediacare®) or pain medicines (e.g., methadone, propoxyphene, tramadol, Darvon®, Dolophine®, Ultram®) while you are using this medicine. Using these medicines together can cause unwanted effects.

    Selegiline may cause serious side effects when used together with some antidepressants. Tell your doctor if you have used amitriptyline, doxepin, fluoxetine, fluvoxamine, nortriptyline, paroxetine, sertraline, Elavil®, Luvox®, Pamelor®, Paxil®, Prozac®, or Zoloft® within the past 14 days.

    When selegiline is taken at doses of 10 mg or less per day for the treatment of Parkinson's disease, there are no restrictions on food or beverages you eat or drink. However, the chance exists that dangerous reactions, such as sudden high blood pressure, may occur if doses higher than those used for Parkinson's disease are taken with certain foods, beverages, or other medicines. These foods, beverages, and medicines include:

    • Foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses; fava or broad bean pods; yeast or meat extracts; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; sauerkraut; or any overripe fruit. If a list of these foods and beverages is not given to you, ask your doctor to provide one.
    • Alcoholic beverages or alcohol-free or reduced-alcohol beer and wine.
    • Large amounts of caffeine-containing food or beverages such as coffee, tea, cola, or chocolate.
    • Any other medicine unless approved or prescribed by your doctor. This especially includes nonprescription (over-the-counter [OTC]) medicine, such as that for colds (including nose drops or sprays), cough, asthma, hay fever, and appetite control; “keep awake” products; or products that make you sleepy.

    Also, for at least 2 weeks after you stop taking this medicine, these foods, beverages, and other medicines may continue to react with selegiline if it was taken in doses higher than those usually used for Parkinson's disease.

    Check with your doctor or hospital emergency room immediately if severe headache, stiff neck, chest pains, fast heartbeat, or nausea and vomiting occur while you are taking this medicine. These may be symptoms of a serious side effect that should have a doctor's attention.

    Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

    Selegiline may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

    It is important that your doctor check your skin for melanoma (tumor) regularly if you have Parkinson's disease.

    Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

    Hallucinations may occur in some patients. This is more common with elderly patients. If you have hallucinations, check with your doctor.

    Some people who have used this medicine had unusual changes in their behavior. Talk with your doctor if you start having problems with gambling or increased sex drive while using this medicine.


    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    More common
    Chest pain (severe)
    enlarged pupils
    fast or slow heartbeat
    headache (severe)
    increase in unusual movements of the body
    increased sensitivity of the eyes to light
    increased sweating (possibly with fever or cold, clammy skin)
    mood or other mental changes
    nausea and vomiting (severe)
    stiff or sore neck

    Less common or rare
    Bloody or black, tarry stools
    convulsions (seizures)
    decreased urine
    difficult or frequent urination
    difficulty with breathing
    difficulty with speaking
    difficulty with swallowing
    dizziness or lightheadedness, especially when getting up from a lying or sitting position
    dry mouth
    hallucinations (seeing, hearing, or feeling things that are not there)
    increased thirst
    irregular heartbeat
    large, flat, blue, or purplish patches in the skin
    lip smacking or puckering
    loss of appetite
    loss of balance control
    muscle pain or cramps
    nausea or vomiting
    numbness or tingling in the hands, feet, or lips
    puffing of the cheeks
    rapid or worm-like movements of the tongue
    restlessness or desire to keep moving
    severe stomach pain
    shakiness in the legs, arms, hands, or feet
    shortness of breath
    swelling of the feet or lower legs
    swelling or inflammation of the mouth
    tightness in the chest
    trembling or shaking of the hands or feet
    twisting movements of the body
    uncontrolled chewing movements
    uncontrolled movements of the face, neck, back, arms, or legs
    unusual tiredness or weakness
    vomiting of blood or material that looks like coffee grounds

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose
    Agitation or irritability
    chest pain
    difficulty opening the mouth or lockjaw
    dizziness (severe) or fainting
    fast or irregular pulse (continuing)
    high fever
    high or low blood pressure
    severe spasm where the head and heels are bent backward and the body arched forward
    troubled breathing

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common
    Abdominal or stomach pain
    dizziness or feeling faint
    runny nose
    stuffy nose
    trouble with sleeping

    Less common or rare
    back or leg pain
    blurred or double vision
    body aches or pain
    burning of the lips, mouth, or throat
    dryness or soreness of the throat
    frequent urge to urinate
    inability to move
    increased sweating
    irritability (temporary)
    memory problems
    pounding or fast heartbeat
    red, raised, or itchy skin
    ringing or buzzing in the ears
    slow or difficult urination
    slowed movements
    taste changes
    uncontrolled closing of the eyelids
    unusual feeling of well-being
    unusual weight loss
    voice changes

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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